Increased plasma cholinesterase activity and succinylcholine resistance: a genetic variant.
نویسنده
چکیده
منابع مشابه
RELATIONSHIP BETWEEN SUCCINYLCHOLINEINDUCED APNEA AND DIBUCAINE NUMBER IN PATIENTS WITH GENETIC DEFICIENCY OF PLASMA CHOLINESTERASE
In this study, a commercially available kit in which propionylthiocholine is used as a substrate and a dibucaine solution to determine the variants of the enzyme were utilized. Plasma cholinesterase activity of 151 patients who underwent different operations was measured during a period of six months. The mean±SD of the enzyme activity in 150 patients was 4.39±1.17 kU/L .. Seventeen patie...
متن کاملRecovery of residual curarization after red blood cell transfusion
BACKGROUND The muscle-relaxing effects of succinylcholine are terminated via hydrolysis by plasma cholinesterase. There are multiple genetic variants of this enzyme and clinical circumstances that might influence the activity of plasma cholinesterase and eventually lead to prolonged neuromuscular blockade following succinylcholine application. CASE REPORT Here, we report a parturient woman wi...
متن کاملGenetic variants of human serum cholinesterase influence metabolism of the muscle relaxant succinylcholine.
People with genetic variants of cholinesterase respond abnormally to succinylcholine, experiencing substantial prolongation of muscle paralysis with apnea rather than the usual 2-6 min. The structure of usual cholinesterase has been determined including the complete amino acid and nucleotide sequence. This has allowed identification of altered amino acids and nucleotides. The variant most frequ...
متن کاملA new succinylcholine-based assay of plasma cholinesterase.
We describe a new method for measuring the in vitro rate of hydrolysis of the muscle relaxant succinylcholine. This substrate is hydrolyzed by plasma cholinesterase (EC 3.1.1.8). The resulting choline is determined by measuring the hydrogen peroxide formed on its oxidation by choline oxidase (EC 1.1.3.17). This is done by use of phenol and aminoantipyrine coupled to peroxidase, and yields an in...
متن کاملNeuromuscular effects of mivacurium in 2- to 12-yr-old children with burn injury.
BACKGROUND Burned patients are usually resistant to the neuromuscular effects of nondepolarizing relaxants, mostly because of receptor changes. The magnitude of the resistance is related to burn size and time after burn. Mivacurium is a muscle relaxant, degraded by plasma cholinesterase, whose enzyme activity is decreased in burns. The present study tested the hypothesis that burn-induced depre...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- The Journal of clinical investigation
دوره 45 3 شماره
صفحات -
تاریخ انتشار 1966